Description

• Title:
  Osilodrostat therapy in a 26-year-old patient after ineffective surgical treatment of Cushing Disease: a case report
• Creator:
  Kamińska, Magdalena;
  Strzoda, Adam;
  Juda, Agata;
  Rojek, Kornelia;
  Strzoda, Anna;
  Sowiński, Wojciech;
  Polak, Agnieszka
• Description:
  Cushing’s Disease is caused by pituitary adenoma which produces adrenocorticotropic hormone causing hypercortisolemia. First-line treatment involves operative removal of the tumor, however, in some patients it proves ineffective. In those cases, pharmacological treatment is necessary as untreated Cushing’s Disease may be lethal. In 2020 a new steroidogenesis inhibitor – Osilodrostat - was approved by the European Medicines Agency and can be used in the treatment of patients who cannot undergo pituitary surgery or whose previous surgical treatment proved ineffective. We present a case of a 26-year-old female patient who was diagnosed with endogenous Cushing’s Disease and underwent two consecutive operations to remove the tumor - both were ineffective. With deteriorating laboratory results and other pharmacological treatments exhausted Osilodrostat therapy was introduced. Osilodrostat is becoming an important drug in patients with Cushing’s Disease refractory to other treatments.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2022 Magdalena Kamińska, Adam Strzoda, Wojciech Sowiński, Agata Juda, Kornelia Rojek, Anna Strzoda, Agnieszka Polak
• Date:
  2022.12.02
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 13 No. 1 (2023); 203-208;
  Journal of Education, Health and Sport; Tom 13 Nr 1 (2023); 203-208;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/40943/33878
• Subject:
  ACTH-dependent Cushing syndrome;
  Osilodrostat;
  Steroidogenesis Inhibitor
• Identifier: https://apcz.umk.pl/JEHS/article/view/40943
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text