Description

• Title:
  The potential impact of glycine supplementation on the process of aging
• Creator:
  Wójcikiewicz, Michalina;
  Julia Kulbacka;
  Czyż, Witold;
  Kacperczyk, Julia;
  Dziedzic, Karol;
  Chuncia, Marta;
  Wojszczyk, Maciej;
  Zys, Damian;
  Pasek, Piotr;
  Ryniecka, Julia;
  Czaja, Wiktor;
  Krzciuk, Michał
• Description:
  Aging is a multifactorial process characterized by the progressive loss of cellular integrity, metabolic flexibility, mitochondrial function, and the gradual accumulation of oxidative and inflammatory damage. These changes increase vulnerability to age-related disorders, including cardiovascular disease, neurodegenerative conditions, metabolic syndrome, and frailty. Glycine, the simplest amino acid, has recently gained attention as a potential nutritional and therapeutic intervention to modulate various pathways implicated in aging. Beyond its structural role in collagen and other proteins, glycine is a critical precursor for glutathione- an essential intracellular antioxidant- plays a role in neurotransmission, and is involved in the synthesis of heme, creatine, and bile acids. Emerging studies suggest that glycine supplementation may alleviate oxidative stress, dampen chronic low-grade inflammation, improve insulin sensitivity, enhance mitochondrial function, and even mimic aspects of methionine restriction- a dietary approach known to extend lifespan in animal models. These combined effects may help preserve physiological function, slow the onset of age-associated diseases, and promote healthspan. Nevertheless, the evidence base is still evolving; most current data derive from animal models, in vitro experiments, and limited human trials. Rigorous, long-term, randomized controlled studies are needed to identify optimal dosing, determine long-term safety, and clarify whether glycine can be strategically leveraged as an anti-aging nutrient. If confirmed, glycine’s safety, affordability, and accessibility may make it a compelling option for improving the quality of aging worldwide. 
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Michalina Wójcikiewicz, Julia Kulbacka, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia-Ileczko, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk
• Date:
  2025.02.01
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 38 (2025); 57686;
  Quality in Sport; Vol. 38 (2025); 57686;
  2450-3118
• Format:
  application/pdf
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/57686/41346
• Subject:
  glycine;
  aging;
  longevity;
  oxidative stress;
  inflammation;
  mitochondria;
  glutathione;
  metabolic health;
  safety;
  bioavailability
• Identifier: https://apcz.umk.pl/QS/article/view/57686
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text