Object's details: Morphofunctional changes in the rat's liver of different ages after L-methionine administration

Provider:Akademicka Platforma Czasopism

Description

Title:
Morphofunctional changes in the rat's liver of different ages after L-methionine administration
Creator:
Yanko, Roman;
Chaka, Elena;
Levashov, Mikhail
Description:
Background: Literature data on the effect of methionine on functional activity and, especially, on morphological changes in the liver parenchyma in animals of different ages are sporadic, and research results are often ambiguous. Aim: The purpose of this work was to study and compare the morphofunctional changes in the liver of rats of different ages on prolonged administration of L-methionine. Material and Methods: The experiment was performed on 48 male Wistar rats of 3 and 15 months of age. Animals of the experimental group received L-methionine at a dose of 250 mg/kg body weight in addition to the standard diet, daily for 21 days. Histological preparations were prepared from liver tissue by a standard technique. Morphometry was performed on digital images using the computer program «Image J». Succinate dehydrogenase activity and protein concentration were determined in the suspension of hepatocyte mitochondria. Results: It was revealed that 21-day administration of L-methionine to rats led to hypertrophy of the hepatocyte nucleus, an increase in the nuclear-cytoplasmic ratio, the number of binuclear hepatocytes, and the nucleolus in the cell nucleus. The relative area of the sinusoids network increased by 50% in 3-month-old animals. This indicated a better blood filling of the liver parenchyma. The increase in succinate dehydrogenase activity and protein concentration was revealed in the suspension of hepatocyte mitochondria of the experimental rats. This indicated an increase in the mitochondria energy potential and protein-synthetic activity. Conclusions: The administration of prophylactic doses of methionine to healthy rats leads to the appearance of pronounced morphological and functional signs of increased activity of hepatocytes. The severity of this effect has a distinct age-dependent character. In young rats, it is more pronounced than in mature rats. The results of the study are important for practical medicine when using methionine for therapeutic and prophylactic purposes.
Object availability:
free access
Rights:
Prawa autorskie (c) 2022 Roman Yanko, Elena Chaka, Mikhail Levashov;
http://creativecommons.org/licenses/by-nc-sa/4.0
Date:
2022.01.14
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 12 No. 1 (2022); 125-137;
Journal of Education, Health and Sport; Tom 12 Nr 1 (2022); 125-137;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/37162/31437
Subject:
methionine;
liver
Identifier: https://apcz.umk.pl/JEHS/article/view/37162
Data provider:
Akademicka Platforma Czasopism

Similar objects

Morphofunctional changes in the rat's liver of different ages after L-methionine administration

Creator:Yanko, Roman | Chaka, Elena | Levashov, Mikhail

Date:2022.01.14

Type:text

Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin

Creator:Yanko, Roman | Levashov, Mikhail | Chaka, Elena | Safonov, Sergey

Date:2021.01.15

Type:text

Seasonal features of the combined effects of intermittent normobabic hypoxia and melatonin on the thyroid gland morphofunctional state

Creator:Yanko, Roman | Levashov, Mikhail | Chaka, Elena | Litovka, Irina | Safonov, Sergey

Date:2020.04.27

Type:text

The role of chemokines in liver disease

Creator:Sapuła, Klaudia | Gołacki, Jakub | Marczak, Aleksandra | Hordejuk, Michalina | Iwaszko-Sochal, Klaudyna

Date:2022.07.14

Type:text

Hepatoepithelioid hemangioendothelioma (HEHE): A comprehensive review of pathogenesis, characteristic features, diagnostic strategies and treatment approaches with the emphasis of surgical therapies

Date:2025.07.09

Type:text

Exploring Haptoglobin as a Promising Marker for Severe Liver Diseases: A Comprehensive Review

Date:2024.11.12

Type:text

Autoimmune hepatitis as a rare cause of cirrhosis development

Date:2024.02.04

Type:text

Ameliorative effect of emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the kidney and liver of mice

Creator:Chakraborty, Devjani | Verma, Ramtej

Date:2010

Type:other

Federacja Bibliotek Cyfrowych

Object's details: Morphofunctional changes in the rat's liver of different ages after L-methionine administration

Description

Similar objects