Description

• Title:
  Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer
• Creator:
  Malinowska, Katarzyna;
  Kaczmarczyk, Dariusz;
  Zajdel, Radosław;
  Merecz-Sadowska, Anna;
  Olszewski, Jurek;
  Majczyk, Małgorzata;
  Nowak-Zduńczyk, Alicja;
  Zielińska-Bliźniewska, Hanna
• Contributor:
  Zakład Alergologii i Rehabilitacji Oddechowej, II Katedra Otolaryngologii, Uniwersytet Medyczny w Łodzi;
  Katedra Otolaryngologii, Uniwersytet Medyczny w Łodzi;
  Katedra Informatyki Ekonomicznej, Uniwersytet Łódzki;
  Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics, USK WAM, Lodz, II Department of Otolaryngology, Medical University of Lodz, Poland;
  Zakład Fizjologii Człowieka, Uniwersytet Medyczny w Łodzi;
  Wyższa Szkoła Biznesu i Nauk o Zdrowiu w Łodzi
• Description:
  Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.
• Object availability:
  free access
• Rights: http://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Uznanie autorstwa-Użycie niekomercyjne-Na tych samych warunkach 4.0 Międzynarodowe
• Date:
  2021.12.16;
  2020
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Elsevier
• Relation:
  Otolaryngologia Polska;74;
  1
• Subject:
  antioxidant enzymes;
  head and neck cancer;
  oxidative stress;
  Pd (II) complexes;
  reactive oxygen species
• Identifier:
  Malinowska K., Kaczmarczyk D., Zajdel R., Merecz-Sadowska A., Olszewski J., Majczyk M., Nowak-Zdunczyk A., Zielinska- Blizniewska H.: Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer; Otolaryngol Pol 2020; 74 (1): 23-28;
  0030-6657;
  http://hdl.handle.net/11089/40071 ;
  2300-8423;
  10.5604/01.3001.0013.3216
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  seek permission
• Type:
  image