Object's details: Expanding the knowledge of Helicobacter pylori – new directions, new challenges

Provider:Akademicka Platforma Czasopism

Description

Title:
Expanding the knowledge of Helicobacter pylori – new directions, new challenges
Creator:
Wronecki, Jakub;
Tywanek, Ewa;
Trojanowska, Paulina;
Skrzydło-Radomańska, Barbara;
Zwolak, Agnieszka;
Łuczyk, Robert Jan
Description:
IntroductionHelicobacter pylori (H. pylori) infection is prevalent worldwide. As it is a known carcinogen, causing multitude of gastrointestinal end extra-gastric disorders, the eradication therapy is now indicated for every patient diagnosed with this infection. This approach may prove however to be improper, since it is now known, that not every strain of this species is pathogenic, therapy may be unsuccessful and drug resistance is ever increasing problem.A brief description of the state of knowledge:H. pylori is a species representing multiple strains with distinct regional genetic markup. Its prevalence is high in the general population, but in the recent years there have been reports of decreased presence in the developed countries. This paper reviews most important known genetic diversity markers and their impact on virulence and toxicity of species. It also covers possible new ways to combat the infection.ConclusionWith increased possibility of genetic sequencing, there may be possibility for custom-tailored eradication therapy of H. pylori in the future.;
SummaryIntroductionHelicobacter pylori (H. pylori) infection is prevalent worldwide. As it is a known carcinogen, causing multitude of gastrointestinal end extra-gastric disorders, the eradication therapy is now indicated for every patient diagnosed with this infection. This approach may prove however to be improper, since it is now known, that not every strain of this species is pathogenic, therapy may be unsuccessful and drug resistance is ever increasing problem.A brief description of the state of knowledge:H. pylori is a species representing multiple strains with distinct regional genetic markup. Its prevalence is high in the general population, but in the recent years there have been reports of decreased presence in the developed countries. This paper reviews most important known genetic diversity markers and their impact on virulence and toxicity of species. It also covers possible new ways to combat the infection.ConclusionWith increased possibility of genetic sequencing, there may be possibility for custom-tailored eradication therapy of H. pylori in the future.Key Words: Helicobacter pylori, genetics, pathogenicity, analysis
Object availability:
free access
Rights:
Prawa autorskie (c) 2020 © The Author(s)
Date:
2020.09.26
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 10 No. 9 (2020); 770-776;
Journal of Education, Health and Sport; Tom 10 Nr 9 (2020); 770-776;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.09.093/26663
Subject:
Helicobacter pylori;
genetics;
pathogenicity;
analysis
Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.09.093
Data provider:
Akademicka Platforma Czasopism

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