Description

• Title:
  Comparison of the mechanisms of action of antidepressants and their side effects
• Creator:
  Wasielewska, Magdalena
• Description:
  Introduction: There are 4 groups of LPs divided according to the mechanism of action. They act on the brain by modulating monoaminergic systems, causing a series of side effects such as insomnia, sedation, anxiety, and a problem of a sexual nature. By appropriately selecting the drug and its dose, the negative effects of the therapy can be avoided.Aim : Comparison of the mode of action of a drug from a given group of antidepressants and description of its side effects.State of knowledge : An example from the first group of drugs with a receptor mechanism of action is trazodone - it acts on many receptors. The combined effect of the drug on all three receptors will significantly improve sleep in all its phases. It is as effective a drug as TLPD, and due to the lack of anticholinergic and cardiotoxic effects, it has a better tolerance and safety profile. It works quickly and improves sleep parameters, which is responsible for faster improvement of the patient's mental state. An example of a drug from the second group of drugs with a different mechanism of action is agomelatine. It is a synthetic analog of melatonin. The simultaneous agonist action on one receptors and antagonist action on the other causes a number of changes in the CNS, which are responsible for the antidepressant effect. The effects of the treatment can be seen after 2 weeks of use. The drug of the third groupneurotransmitter reuptake inhibitorsthere is bupropion. It intensifies the dopaminergic transmission. It does not disturb the sexual sphere, but increases insomnia as a side effect.Summary : By selecting the appropriate LP and its dose, side effects can be avoided.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2020 © The Author(s)
• Date:
  2020.08.20
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 10 No. 8 (2020); 260-267;
  Journal of Education, Health and Sport; Tom 10 Nr 8 (2020); 260-267;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.08.030/26341
• Subject:
  depression;
  mental disorders;
  antidepressants;
  side effects
• Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.08.030
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text