Description

• Title:
  Radiotherapy for non-malignant diseases in orthopaedics: efficacy and safety
• Creator:
  Wiśniowska, Ada;
  Wiśniowski, Maksymilian;
  Kozłowska, Aleksandra
• Description:
  Introduction: This review aims to assess the current evidence on the efficacy and safety of low-dose radiotherapy (LDRT) in the treatment of non-malignant musculoskeletal and orthopaedic disorders, including osteoarthritis, plantar fasciitis, calcaneal spur, enthesopathies, Dupuytren’s contracture, Ledderhose disease, and heterotopic ossification. As the prevalence of such conditions rises due to aging populations and modern lifestyle factors, interest is growing in alternative therapies for patients unresponsive to standard conservative treatment. State of the Art: LDRT has been used in Germany for decades and is now gaining wider clinical attention. Its mechanisms—primarily anti-inflammatory and immunomodulatory—include suppression of pro-inflammatory cytokines and modulation of macrophage phenotypes. Recent studies show pain reduction in 42–95% of patients, with complete remission in up to 81%, depending on the condition, dosage, and treatment schedule. Comparable efficacy is seen between lower (0.5 Gy/fraction) and higher (1.0 Gy/fraction) dosing regimens. LDRT has shown particular benefit in early-stage fibromatoses and in postoperative prevention of heterotopic ossification, where combination with NSAIDs enhances efficacy. Safety data indicate minimal adverse effects and no significant increase in malignancy risk. However, some randomized trials report outcomes similar to placebo, highlighting the need for further controlled research. Conclusions: LDRT is a safe and promising adjunctive therapy in selected orthopaedic conditions, especially where conventional treatments have failed or are contraindicated. While long-term safety appears acceptable, further sham-controlled trials, biomarker studies, and treatment standardization are essential. This review is primarily intended for clinicians seeking evidence-based alternatives for managing chronic musculoskeletal disorders.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Ada Wiśniowska, Maksymilian Wiśniowski, Aleksandra Kozłowska
• Date:
  2025.07.03
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 83 (2025); 60697;
  Journal of Education, Health and Sport; Tom 83 (2025); 60697;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/60697/43080
• Subject:
  radiotherapy;
  non-malignant diseases;
  osteoarthritis;
  plantar fasciitis;
  heterotopic ossification;
  Dupuytren’s contracture;
  Ledderhose;
  Gorham-Stout
• Identifier: https://apcz.umk.pl/JEHS/article/view/60697
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text