Description

• Title:
  Theophylline Revisited. Mechanisms, Challenges, and New Horizons
• Creator:
  Szarłowicz, Jakub;
  Mazur, Michał;
  Waz, Dorota;
  Goliszek, Zofia;
  Sobek, Karolina Łucja;
  Tabin-Barczak, Wiktoria;
  Sokołowska, Aldona;
  Fikas, Klaudia;
  Chwaliszewski, Kamil;
  Samuła, Sebastian
• Description:
  Introduction and Purpose Theophylline, used for over a century in asthma and COPD treatment, provides anti-inflammatory and bronchodilatory effects via phosphodiesterase inhibition and adenosine receptor antagonism. This review examines its mechanisms, clinical uses, and emerging applications. Materials and Methods A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine. Results Theophylline shows anti-inflammatory effects, mitochondrial support, and modulation of key pathways (e.g., PI3K/Akt, NF-κB). It demonstrates potential in COVID-19-related ARDS, promoting muscle regeneration, and treating infertility. However, its narrow therapeutic index and variability in pharmacokinetics remain significant challenges. Conclusion Theophylline remains a cost-effective option in asthma and COPD and shows promise in broader applications like immunomodulation and metabolic disorders. Further research and advanced drug formulations are needed to enhance its safety and therapeutic potential.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Jakub Szarłowicz, Michał Mazur, Dorota Waz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła
• Date:
  2025.01.02
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 37 (2025); 57009;
  Quality in Sport; Vol. 37 (2025); 57009;
  2450-3118
• Format:
  application/pdf
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/57009/40942
• Subject:
  Theophylline;
  Asthma;
  COPD;
  adenosine antagonist;
  immunomodulation;
  mitochondria;
  COVID-19;
  anti-inflammatory
• Identifier: https://apcz.umk.pl/QS/article/view/57009
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text