Description

• Title:
  SWI/SNF-type complexes–transcription factor interplay: a key regulatory interaction
• Creator:
  Maassen, Anna*;
  Steciuk, Jarosław*;
  Wilga, Magdalena;
  Szurmak, Jakub;
  Garbicz, Damian;
  Sarnowska, Elzbieta;
  Sarnowski, Tomasz
• Description:
  ATP-dependent switch/sucrose nonfermenting-type chromatin remodeling complexes (SWI/SNF CRCs) are multiprotein machineries altering chromatin structure, thus controlling the accessibility of genomic DNA to various regulatory proteins including transcription factors (TFs). SWI/SNF CRCs are highly evolutionarily conserved among eukaryotes. There are three main subtypes of SWI/SNF CRCs: canonical (cBAF), polybromo (pBAF), and noncanonical (ncBAF) in humans and their functional Arabidopsis counterparts SYD-associated SWI/SNF (SAS), MINU-associated SWI/SNF (MAS), and BRAHMA (BRM)-associated SWI/SNF (BAS). Here, we highlight the importance of interplay between SWI/SNF CRCs and TFs in human and Arabidopsis and summarize recent advances demonstrating their role in controlling important regulatory processes. We discuss possible mechanisms involved in TFs and SWI/SNF CRCs-dependent transcriptional control of gene expression. We indicate that Arabidopsis may serve as a valuable model for the identification of evolutionarily conserved SWI/SNF–TF interactions and postulate that further exploration of the TFs and SWI/SNF CRCs-interplay, especially in the context of the role of particular SWI/SNF CRC subtypes, TF type, as well as cell/tissue and conditions, among others, will help address important questions related to the specificity of SWI/SNF–TF interactions and the sequence of events occurring on their target genes.
• Object availability:
  free access
• Date:
  2025
• Type:
  Article;
  PeerReviewed
• Language:
  English
• Format:
  text/html
• Relation: http://eprints.ibb.waw.pl/2534 ;https://doi.org/10.1186/s11658-025-00704-y
• Subject:
  Q Science (General)
• Identifier: http://eprints.ibb.waw.pl/2534/1/10.1186/s11658-025-00704-y ;
  Maassen, Anna* and Steciuk, Jarosław* and Wilga, Magdalena and Szurmak, Jakub and Garbicz, Damian and Sarnowska, Elzbieta and Sarnowski, Tomasz (2025) SWI/SNF-type complexes–transcription factor interplay: a key regulatory interaction. Cellular & Molecular Biology Letters, 30 . p. 30.
• Data provider:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
• Can I use it?:
  seek permission
• Type:
  other