Description

• Title:
  The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review
• Creator:
  Papa, Veronica;
  Galassi, Franceso M.;
  Varotto, Elena;
  Gori, Andrea;
  Vaccarezza, Mauro
• Contributor:
  Forensic Anthropology, Paleopathology and Bioarchaeology (FAPAB) Research Center, Avola, Italy; Department of Economics, Law, Cybersecurity, and Sports Sciences, University of Naples “Parthenope,” Naples, Italy; School of Science, Engineering and Health, University of Naples “Parthenope,” Naples, Italy;
  Forensic Anthropology, Paleopathology and Bioarchaeology (FAPAB) Research Center, Avola, Italy; Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237, Lodz, Poland;
  Forensic Anthropology, Paleopathology and Bioarchaeology (FAPAB) Research Center, Avola, Italy; Archaeology, College of Humanities, Arts and Social Sciences, Flinders University, Adelaide, SA, Australia;
  I Division of Infectious Diseases, “Luigi Sacco” Hospital, ASST Fatebenefratelli Sacco, Milan, Italy; Department of Pathophysiology and Transplantation, Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy;
  Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Perth, 6102 Western Australia, Australia; Curtin Health Innovation Research Institute (CHIRI), Faculty of Health Sciences, Curtin University, Bentley, Perth, 6102 Western Australia, Australia
• Description:
  Tuberculosis (TB) is an ancient chronic infectious disease that remains a global health concern. In human remains, the most common and characteristic clinical signs are the skeletal modifications involving the spine, such as in Pott’s disease. Diagnosing TB in ancient human remains is challenging. Therefore, in this systematic review, the authors investigated the studies assessing molecular diagnosis of Pott’s disease in ancient human remains with the intention to survey the literature, map the evidence, and identify gaps and future perspectives on TB in paleopathology. Our systematic review offers a full contextualization of the history of Pott’s disease in ancient times. Our search strategy was performed between August 2022 and March 2023. The authors initially identified 340 records, and 74 studies were finally included and assessed for qualitative analysis. Due to non-specific clinical signs associated with TB, how best to diagnose tuberculosis in human remains still represents a central point. Nevertheless, ancient DNA (aDNA) analysis, lipid biomarkers, and spoligotyping might be extremely useful tools in the study of TB in human remains. Moreover, we propose the extraction and study of immune response genes involved in innate and adaptive immunity versus Mycobacterium spp. as an innovative and vastly overlooked approach in TB paleopathology. Complementary methodologies should be integrated to provide the best approach to the study of TB in human remains.
• Object availability:
  free access
• Rights:
  Uznanie autorstwa 4.0 Międzynarodowe;
  http://creativecommons.org/licenses/by/4.0
• Date:
  2023.10.27;
  2023
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Case Western Reserve University
• Relation:
  Pathogens and Immunity;1;
  8
• Subject:
  Tuberculosis;
  spondylodiscitis;
  ancient DNA;
  Mycobacterium Tuberculosis Complex (MTBC);
  human remains
• Identifier:
  Papa V, Galassi FM, Varotto E, Gori A, Vaccarezza V. The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review. Pathogens and Immunity. 2023;8(1):93– 116. doi: 10.20411/pai.v8i1.597;
  2469-2964;
  http://hdl.handle.net/11089/48202 ;
  10.20411/pai.v8i1.597
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  check license
• Type:
  image