Description

• Title:
  Advancements In Biological Treatment Of Takayasu Arteritis: Efficacy, Safety, And Future Perspectives
• Creator:
  Cygnarowicz, Aleksandra;
  Maciaszek, Oliwia;
  Biskupski , Mikołaj;
  Turemka, Mariola;
  Chmiel, Marianna;
  Tumiński, Artur;
  Mandziuk, Aneta;
  Zabojska, Krystyna
• Description:
  Introduction and Objective Takayasu's arteritis (TAK) is a chronic autoimmune vasculitis that primarily impacts the aorta and its major branches. The standard treatment has been glucocorticoids; however, their prolonged usage can cause severe side effects, and many patients fail to maintain sustained remission. This review aims to assess the recent advances in utilizing biological drugs for treating TAK, with a focus on their efficacy and safety profiles.  Methods  To conduct this review, we analyzed clinical trials, retrospective studies, and case reports. The databases searched included PubMed, MEDLINE, and Scopus utilizing keywords like "Takayasu arteritis," "biological treatment," and specific medication names.   Brief Description of the Current State of Knowledge  Several biological therapies targeting key inflammatory pathways implicated in TAK have demonstrated promise. These include IL-6 inhibitors (tocilizumab), TNF-alpha inhibitors (infliximab, etanercept), and JAK inhibitors (tofacitinib). Clinical research and case reports indicate these therapies can decrease disease activity, facilitate glucocorticoid tapering, and enhance quality of life in patients who do not sufficiently respond to standard treatment. However, concerns remain about long-term safety, including heightened infection risk and paradoxical inflammatory reactions.  Summary  Biological medications represent a major step forward in TAK treatment, providing hope for individuals unresponsive to conventional approaches. However, additional large-scale, randomized controlled trials are needed to establish their long-term efficacy and safety of the treatment.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2025 Aleksandra Cygnarowicz, Oliwia Maciaszek, Mikołaj Biskupski , Mariola Turemka, Marianna Chmiel, Artur Tumiński, Aneta Mandziuk, Krystyna Zabojska;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2025.03.06
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 79 (2025); 57867;
  Journal of Education, Health and Sport; Tom 79 (2025); 57867;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/57867/41733
• Subject:
  Takayasu’s arteritis (TA);
  biological treatment;
  IL-6 inhibitors;
  TNF-alpha inhibitors
• Identifier: https://apcz.umk.pl/JEHS/article/view/57867
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text