Description

• Tytuł:
  Glucagon-like peptide-1 receptor agonists as a Therapeutic Option for Antipsychotic-Induced Obesity: A Review of Current Evidence
• Twórca:
  Gniaź, Natalia;
  Górska, Aleksandra;
  Grela, Wiktor;
  Niewiadomska, Jagoda;
  Furtak, Daria;
  Tulej, Dawid;
  Głogowska, Paulina;
  Dziedzic, Alicja;
  Marciniuk, Dominika;
  Marko, Natalia
• Opis:
  IntroductionObesity affects over 650 million adults worldwide and is a major risk factor for cardiovascular diseases and type 2 diabetes. Among those affected are patients treated with antipsychotics, such as clozapine and olanzapine, which often lead to significant weight gain, increasing the risk of metabolic syndrome. Recent advances with glucagon-like peptide-1 receptor agonists (GLP-1 RAs), including semaglutide and liraglutide, show promise in addressing antipsychotic-induced obesity by reducing weight and improving metabolic health. PurposeThe aim of this review is to present an overview of the current state of knowledge regarding the efficacy of GLP-1 RAs in the treatment of antipsychotic-induced obesity. Materials and methodsThis review is based on both original research studies and review articles identified through a comprehensive search of the PubMed database, using the following search terms: obesity, antipsychotic-induced weight gain, clozapine, olanzapine, adverse effect, GLP-1 receptors agonist.  Description of the state of knowledgeGLP-1 RAs significantly reduce body weight and adipose tissue by suppressing appetite, particularly for high-fat foods. Clinical trials show improvements in lipid profiles, blood pressure, and inflammation, contributing to better metabolic health. However, their long-term effects, especially with different antipsychotics, remain insufficiently studied. ConclusionsGLP-1 RAs show significant potential for managing antipsychotic-induced obesity, but further research is needed to assess long-term efficacy and safety in this population.
• Dostępność obiektu:
  free access
• Prawa:
  Prawa autorskie (c) 2024 Natalia Gniaź, Aleksandra Górska, Wiktor Grela, Jagoda Niewiadomska, Daria Furtak, Dawid Tulej, Paulina Głogowska, Alicja Dziedzic, Dominika Marciniuk, Natalia Marko;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Data:
  2024.12.07
• Typ:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Język:
  English
• Źródło:
  Journal of Education, Health and Sport; Vol. 75 (2024); 56672;
  Journal of Education, Health and Sport; Tom 75 (2024); 56672;
  2391-8306
• Format:
  application/pdf
• Wydawca:
  Nicolaus Copernicus University, Toruń, Poland
• Relacja: https://apcz.umk.pl/JEHS/article/view/56672/40569
• Temat i słowa kluczowe:
  obesity;
  antipsychotic-induced weight gain;
  clozapine;
  olanzapine;
  adverse effect;
  GLP-1 receptors agonist
• Identyfikator: https://apcz.umk.pl/JEHS/article/view/56672
• Dostawca danych:
  Akademicka Platforma Czasopism
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