Description

• Title:
  Effectiveness of Bacterial Lysates as Immune-Boosting Supplements: Evaluating a Novel Approach to Immune Health
• Creator:
  Mąsior, Gabriela;
  Dowgiert, Szymon;
  Ambroziewicz, Zuzanna;
  Siemiątkowski, Robert;
  Łata, Michał;
  Chruściel, Joanna;
  Grabowska, Hanna;
  Kamiński, Jakub;
  Więcław, Katarzyna;
  Sikorska, Małgorzata
• Description:
  The increasing prevalence of recurrent infections and immune-related disorders has intensified the search for effective immune-modulating interventions. Bacterial lysates, derived from inactivated bacterial components, have emerged as promising immune-boosting supplements. These lysates activate both innate and adaptive immune responses by interacting with pattern recognition receptors such as Toll-like receptors (TLRs), triggering signaling pathways that enhance immune surveillance and pathogen recognition. Among the most extensively studied is OM-85, which has demonstrated efficacy in reducing the frequency and severity of respiratory tract infections (RTIs) and modulating immune pathways involved in asthma and allergic rhinitis. This review evaluates the mechanisms of action, clinical efficacy, and safety profiles of bacterial lysates, particularly focusing on their role in preventing RTIs and managing chronic inflammatory diseases. Evidence supports their potential to reduce antibiotic use and improve overall clinical outcomes in both pediatric and adult populations. Despite their general safety, certain contraindications exist, especially in patients with hypersensitivity or autoimmune conditions. Further research is required to optimize their use, particularly in immunocompromised populations and for broader applications, such as viral infections. Bacterial lysates represent a novel, cost-effective approach to enhancing immune health and reducing the global reliance on antibiotics.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2024 Gabriela Mąsior, Szymon Dowgiert, Zuzanna Ambroziewicz, Robert Siemiątkowski, Michał Łata, Joanna Chruściel, Hanna Grabowska, Jakub Kamiński, Katarzyna Więcław, Małgorzata Sikorska;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2024.12.08
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 76 (2024); 56342;
  Journal of Education, Health and Sport; Tom 76 (2024); 56342;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/56342/40578
• Subject:
  bacterial lysate;
  immune boost;
  immunity stimulation;
  infection;
  infection prevention
• Identifier: https://apcz.umk.pl/JEHS/article/view/56342
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text