Description

• Title:
  Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies
• Creator:
  Bakuła, Piotr Robert;
  Jałocha, Kamila;
  Zygadło, Joanna
• Description:
  Osteoarthritis (OA) is a prevalent degenerative joint disease that significantly impacts the quality of life of millions worldwide, particularly the elderly. While conventional non-surgical treatments, such as NSAIDs, intra-articular injections, and physical therapy, provide symptomatic relief, their long-term efficacy and safety remain limited. Recent advancements in understanding OA pathophysiology have spurred the development of innovative therapeutic strategies targeting disease progression. This review examines emerging pharmacological and regenerative approaches, including disease-modifying osteoarthritis drugs (DMOADs), biologics, and cell-based therapies. Cutting-edge technologies such as RNA interference, CRISPR/Cas9, and advanced regenerative medicine are also explored for their potential to revolutionize OA management. Additionally, the integration of novel therapies with traditional interventions is discussed, highlighting opportunities for a more personalized, multimodal approach to OA care. Despite significant progress, challenges such as translational hurdles, cost barriers, and long-term efficacy require further investigation. This review emphasizes the transformative potential of emerging therapies in addressing the unmet needs of OA patients and shaping future treatment paradigms.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło
• Date:
  2025.02.11
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 38 (2025); 58169;
  Quality in Sport; Vol. 38 (2025); 58169;
  2450-3118
• Format:
  application/vnd.openxmlformats-officedocument.wordprocessingml.document
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/58169/41482
• Subject:
  cartilage regeneration;
  osteoarthritis;
  disease-modyfing osteoarthritis drugs;
  emerging therapies;
  pain management;
  cell-based therapies;
  regenerative medicine
• Identifier: https://apcz.umk.pl/QS/article/view/58169
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text