Object's details: RNA-based vaccines – types, strategies of delivery and overview of RNA vaccines

Provider:Akademicka Platforma Czasopism

Description

Title:
RNA-based vaccines – types, strategies of delivery and overview of RNA vaccines
Creator:
Rusinowska, Barbara;
Tybulczuk, Balbina;
Satora, Małgorzata;
Kozioł, Magdalena;
Sikora, Katarzyna
Description:
  The discovery of mRNA by Sydney Brenner dates back to 1961, but the in vivo expression of mRNA was successful only in 1990, which initiated the development of vaccines based on this molecule. During Sars-CoV-2 pandemy the interest in the use of nucleic acids in the production of drugs and vaccines has increased significantly. The success of mRNA vaccines against Sars-CoV-2 has particularly empowered the pharmaceutical industry to create newer and newer generation products based on RNA modification that could help not only in Covid-2019, but also in the prevention and treatment of other infectious diseases. RNA has a very high potential - it can be used in highly personalized therapies, furthermore the production of mRNA is cheaper, faster than the current therapeutics and the process of mRNA making is more flexible due to the great ease of producing mRNA in the process of transcription. Modifying of the structure of ribonucleic acid and the methods of its delivery leads to the creation of newer and newer vaccines. In this review, we present the potential of RNA molecule in producing vaccines, types of RNA vaccines, strategies of RNA delivery and review of existing RNA-based vaccines.
Object availability:
free access
Rights:
Prawa autorskie (c) 2022 Barbara Rusinowska, Balbina Tybulczuk, Małgorzata Satora, Magdalena Kozioł, Katarzyna Sikora;
http://creativecommons.org/licenses/by-nc-sa/4.0
Date:
2022.08.01
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 12 No. 7 (2022); 897-905;
Journal of Education, Health and Sport; Tom 12 Nr 7 (2022); 897-905;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/39218/32864
Subject:
RNA;
mRNA;
vaccines;
NRM;
SAM
Identifier: https://apcz.umk.pl/JEHS/article/view/39218
Data provider:
Akademicka Platforma Czasopism

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