Description

• Title:
  New view on alcoholic liver disease - potential role of PD1/PDL-1 pathway in the disease pathogenesis
• Creator:
  Adamczyk, Katarzyna;
  Kasztelan-Szczerbińska, Beata;
  Rycyk, Anna;
  Cichoż-Lach, Halina
• Description:
  Introduction: Exposure to chronic, excessive alcohol consumption, its breakdown metabolites, and gut-derived endotoxins dysregulate immune signaling leading to activation of inflammation. As a result, the non-resolving inflammatory response and development of alcoholic liver disease (ALD) may occur. There are still no pharmacological or nutritional therapies for treating patients with alcoholic liver disease. Material and Methods: The information provided was collected as a result of various article’s analyses on the development, diagnosis, and treatment of patients with alcoholic liver disease using Google Scholar and PubMed databases. Results: The pathway consisting of the programmed cell death 1 (PD-1) receptor and its ligand PD-L1 may play a critical role in the inhibition of self-reactive and inflammatory effector cells and the protection against immune-mediated tissue damage. There is a possibility of the potential gender-related differences in PD1/PD-L1 signaling in ALD. Conclusion: The better understanding of ALD as a dynamic process and all aspects of immune dysregulation may be important for the development of novel therapies in alcoholic liver disease. Results from a further study on the PD1/PDL-1 pathway might be exploited to re-define therapeutic targets and create sex-tailored treatments according to individual patient needs.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2019 © The Author(s)
• Date:
  2019.11.17
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 9 No. 11 (2019); 121-127;
  Journal of Education, Health and Sport; Tom 9 Nr 11 (2019); 121-127;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2019.09.11.009/23761
• Subject:
  alcohol liver disease (ALD);
  immune dysregulation;
  programmed cell death 1 (PD-1);
  gender difference
• Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2019.09.11.009
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text