Description

• Title:
  The Impact of GLP-1 Agonists on Depression Treatment: A Literature Review
• Creator:
  Lemieszek, Paulina;
  Rudnicka, Katarzyna;
  Sajkiewicz, Ilona;
  Miga-Orczykowska, Nadia;
  Jasiuk, Ilona;
  Wójtowicz, Justyna;
  Pustelniak, Martyna;
  Krukar, Katarzyna;
  Łukaszewska, Ewa;
  Kister, Klaudia;
  Chrościński, Kamil;
  Laskowski, Jakub
• Description:
  Introduction Depression is increasingly recognized as a major global health issue, driven by neurobiological, genetic, and environmental factors. Despite extensive research, understanding depression remains challenging due to its complexity and the lack of biomarkers. Recent studies highlight a link between depression and metabolic disturbances, emphasizing the need for alternative therapeutic approaches. Purpose This review aims to explore the therapeutic potential of GLP-1 (glucagon-like peptide-1) in treating depression, focusing on its impact on neurogenesis, neuroinflammation, neurotransmitter imbalances, and synaptic dysfunction. Materials and Methods A systematic review was conducted by analyzing literature from databases such as PubMed and Google Scholar, covering studies from 2003 to 2024. The review focused on keywords related to GLP-1, depression, and diabetes. Description of the State of Knowledge This section discusses the neurobiological mechanisms of depression, including neuroinflammation, neurotransmitter imbalances, and impaired neurogenesis. It highlights the potential of GLP-1 agonists to address these issues and improve mood and cognitive function. Conclusion The review concludes that GLP-1 holds promise as a therapeutic target for depression. Beyond its metabolic roles, GLP-1 can influence brain regions involved in mood regulation, enhance neurogenesis, reduce neuroinflammation, and improve neurotransmitter balance. These effects suggest that GLP-1-based therapies could offer new treatment options for depression, potentially improving outcomes beyond traditional antidepressants.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2024 Paulina Lemieszek, Katarzyna Rudnicka, Ilona Sajkiewicz, Nadia Miga-Orczykowska, Ilona Jasiuk, Justyna Wójtowicz, Martyna Pustelniak, Katarzyna Krukar, Ewa Łukaszewska, Klaudia Kister, Kamil Chrościński, Jakub Laskowski;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2024.10.02
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 69 (2024); 55353;
  Journal of Education, Health and Sport; Tom 69 (2024); 55353;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/55353/39924
• Subject:
  GLP-1;
  diabetes;
  depression;
  systematic review
• Identifier: https://apcz.umk.pl/JEHS/article/view/55353
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text