Description

• Title:
  Modern biomarkers as key tools in the early diagnosis and monitoring of Alzheimer's disease progression
• Creator:
  Strużek, Konrad;
  Karamus, Kornelia;
  Rejmak, Rafał;
  Borowska-Łygan, Martyna;
  Urban, Wojciech;
  Tomaszewski, Jakub;
  Gryc, Anna;
  Lipiec, Jakub;
  Grudzień, Monika
• Description:
  Advances in the understanding of Alzheimer’s disease (AD) pathophysiology, along with the development of neuroimaging and biomarker analysis, have enabled the detection of neurodegenerative changes even before clinical symptoms appear. This article explores the evolution of AD diagnostic criteria, with a particular focus on the pivotal role of cerebrospinal fluid biomarkers (Aβ42, t-tau, p-tau) and brain imaging techniques (MRI, PET). The A/T/N classification system and the concept of compensatory brain mechanisms are also discussed, emphasizing their relevance in early disease detection. The modern diagnostic approach, introduced by the Dubois criteria and further developed by the NIA-AA framework, allows for the identification of AD in its preclinical phase. The presence of biomarker abnormalities in asymptomatic individuals suggests a long latent period and the activation of neuroplastic compensatory processes that may delay symptom onset. The integration of biomarkers has significantly improved diagnostic accuracy, enhanced clinical trial participant selection, and enabled more precise disease monitoring. Despite these advances, effective treatments to halt or reverse disease progression remain elusive, highlighting the urgent need for further research into compensatory mechanisms, individual variability, and early therapeutic strategies.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Konrad Strużek, Kornelia Karamus, Rafał Rejmak, Martyna Borowska-Łygan, Wojciech Urban, Jakub Tomaszewski, Anna Gryc, Jakub Lipiec, Monika Grudzień
• Date:
  2025.04.29
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 80 (2025); 60238;
  Journal of Education, Health and Sport; Tom 80 (2025); 60238;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/60238/42343
• Subject:
  Alzheimer’s disease;
  biomarkers;
  cerebrospinal fluid;
  neuroimaging;
  Aβ42;
  tau protein;
  A/T/N classification;
  early diagnosis
• Identifier: https://apcz.umk.pl/JEHS/article/view/60238
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text