Object's details: Berberine in obesity therapy: from molecular mechanisms to clinical applications

Provider:Akademicka Platforma Czasopism

Description

Title:
Berberine in obesity therapy: from molecular mechanisms to clinical applications
Creator:
Kamińska-Omasta, Katarzyna;
Omasta, Bartosz;
Romańczuk, Kuba Borys;
Krupa, Olga;
Pietrukaniec, Paulina Dorota;
Wójcik, Zofia Martyna;
Furtak, Kinga;
Stolarczyk, Szymon Przemysław;
Czerska, Magdalena Agata;
Rybak, Daria
Description:
Objective: The study aimed to explore the therapeutic potential of berberine in obesity treatment, with a particular focus on its effects on key metabolic mechanisms, inflammatory processes, and gut microbiota composition. Materials and Methods: This review encompasses an analysis of preclinical and clinical studies examining berberine’s mechanisms of action, including AMPK pathway activation, lipid profile regulation, white adipose tissue browning, and gut microbiota modulation. Data on berberine’s bioavailability and advanced delivery systems were also included. Main results: Studies demonstrate that berberine improves anthropometric parameters (BMI, waist circumference), promotes adipose tissue remodeling, and supports glycemic control. It exhibits anti-inflammatory properties, reduces inflammatory markers, and modulates gut microbiota to enhance metabolic processes. Advanced delivery systems have improved its bioavailability, enhancing clinical efficacy. Conclusions:Berberine shows multifaceted potential as a complementary therapy for obesity, especially when combined with lifestyle interventions. It offers a safe and effective alternative for addressing this global health challenge.
Object availability:
free access
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
Prawa autorskie (c) 2025 Katarzyna Kamińska-Omasta, Bartosz Omasta, Kuba Borys Romańczuk, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak
Date:
2025.02.13
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Quality in Sport; Tom 38 (2025); 58195;
Quality in Sport; Vol. 38 (2025); 58195;
2450-3118
Format:
application/pdf
Publisher:
University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
Relation: https://apcz.umk.pl/QS/article/view/58195/41525
Subject:
berberine;
obesity;
insulin sensitivity;
gut microbiota;
bioavailability
Identifier: https://apcz.umk.pl/QS/article/view/58195
Data provider:
Akademicka Platforma Czasopism

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Object's details: Berberine in obesity therapy: from molecular mechanisms to clinical applications

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