Object's details: Exacerbation of symptoms of rheumatoid arthritis in the course of immunotherapy of non-small cell lung cancer - an analysis of medical cases and a review of the literature

Provider:Akademicka Platforma Czasopism

Description

Title:
Exacerbation of symptoms of rheumatoid arthritis in the course of immunotherapy of non-small cell lung cancer - an analysis of medical cases and a review of the literature
Creator:
Bargieł, Julia;
Cabaj, Justyna;
Chmielewska, Izabela;
Wójcik-Superczyńska, Magdalena;
Milanowski, Janusz
Description:
Background: Lung cancer has been at the forefront of cancers with the highest incidence and mortality rates. Nowadays, there are available more effective forms of treatment such as immunotherapy. In the case of cancer cells expressing the PD-L1 receptor, pembrolizumab, atezolizumab and nivolmab are of particular use. While these drugs have the great benefit of stabilizing the disease, they are not without side effects, especially inflammatory changes in the joints. The aim of the study is to show the risk of immunotherapy in the form of exacerbation of inflammatory symptoms in patients with rheumatoid arthritis (RA) as a concomitant disease. Case report: Lung cancer (PD-L1 +) was diagnosed in three patients with a history of RA. After meeting the criteria of the drug program, the patients started molecularly targeted therapy with pembrolizumab and atezolizumab. The applied treatment brought a great benefit in the form of stabilization the neoplastic disease. Over time an exacerbation of inflammatory changes within the joints was noted, which significantly impeded everyday functioning in two patients. Due to this situation, immunotherapy was discontinued. Conlusions: Studies show that as many as 1/4 of patients treated with PD-L1 inhibitors experience side effects related to the autoimmune system. In the case of people suffering from RA, the use of immunotherapy may intensify inflammatory changes and increase pain, which significantly reduce the quality of life. Therefore, the risk of RA exacerbation as a side effect of biological therapy for lung cancer treatment should be popularized. This awareness will enable quick intervention and minimize the number of interrupted immunotherapies.
Object availability:
free access
Rights: http://creativecommons.org/licenses/by-nc-sa/4.0 ;
Prawa autorskie (c) 2022 Julia Bargieł, Justyna Cabaj, Izabela Chmielewska, Magdalena Wójcik-Superczyńska, Janusz Milanowski
Date:
2022.09.16
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 12 No. 9 (2022); 856-866;
Journal of Education, Health and Sport; Tom 12 Nr 9 (2022); 856-866;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/39968/33270
Subject:
oncology;
immunotherapy;
lung cancer;
rheumatic diseases
Identifier: https://apcz.umk.pl/JEHS/article/view/39968
Data provider:
Akademicka Platforma Czasopism

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Object's details: Exacerbation of symptoms of rheumatoid arthritis in the course of immunotherapy of non-small cell lung cancer - an analysis of medical cases and a review of the literature

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