Object's details: Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients
Creator:
Ambroziak, Urszula;
Kuryłowicz, Alina;
Kępczyńska-Nyk, Anna;
Bartoszewicz, Zbigniew;
Kondracka, Agnieszka;
Jazwiec, Radoslaw;
Samborowska, Emilia;
Dadlez, Michal;
Wysłouch-Cieszyńska, Aleksandra;
Bednarczuk, Tomasz
Description:
Objectives: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. Material and methods: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism. In all participants, anthropometric data, lipids, adipose tissue percent (%fat), HOMA-IR were also assessed. Results: The studied groups were not different in terms of age, BMI, waist circumference, %fat and HOMA-IR. In the patients group, mean TT and androstendione levels were significantly higher as compared to controls (1.4 nmol/L vs. 1.0 nmol/L, P < 0.001) and (6.6 nmol/L vs. 4.9 nmol/L, P < 0.01), respectively. In the patients group, mean TT/DHT ratio was significantly higher compared to controls (3.6 vs. 2.7, P < 0.01) and correlated with BMI (r = 0.37, P < 0.05), waist circumference (r = 0.44, P < 0.01), %fat (r = 0.30, P < 0.05), as well as with insulin levels (r = 0.38, P < 0.05) and HOMA-IR (r = 0.44, P < 0.05). The association between TT/DHT ratio and unfavorable metabolic parameters was also seen in controls. Conclusion: Total testosterone/dihydrotestosterone ratio assessed by LC-MS/MS correlates with a worse metabolic profile not only in PCOS patients, but also in healthy women.
Object availability:
free access
Date:
2017.01
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/1455 ;http://doi.org/10.5603/GP.a2017.0001 ;doi:10.5603/GP.a2017.0001
Subject:
RG Gynecology and obstetrics
Identifier: http://eprints.ibb.waw.pl/1455/1/47871-115724-1-PB.pdf ;
Ambroziak, Urszula and Kuryłowicz, Alina and Kępczyńska-Nyk, Anna and Bartoszewicz, Zbigniew and Kondracka, Agnieszka and Jazwiec, Radoslaw and Samborowska, Emilia and Dadlez, Michal and Wysłouch-Cieszyńska, Aleksandra and Bednarczuk, Tomasz (2017) Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients. Ginekologia Polska, 88 (1). pp. 5-8. ISSN 0017-0011
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients

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