Object's details: Virus-like particles as vaccine.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Virus-like particles as vaccine.
Creator:
Chroboczek, Jadwiga;
Szurgot, Inga;
Szolajska, Ewa
Description:
This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they contain functional viral proteins responsible for cell penetration by the virus, ensuring efficient cell entry and thus tissue-specific targeting, determined by the origin of the virus. The foremost application of VLPs is in vaccinology, where they provide delivery systems that combine good safety profiles with strong immunogenicity and constitute a safe alternative to inactivated infectious viruses. These stable and versatile nanoparticles display excellent adjuvant properties capable of inducing innate and cognate immune responses. They present both, high-density B-cell epitopes, for antibody production and intracellular T- cell epitopes, thus inducing, respectively, potent humoral and cellular immune responses. Uptake of VLPs by antigen-presenting cells leads to efficient immune responses resulting in control of pathogenic microorganisms.
Object availability:
free access
Date:
2014
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/806 ;http://www.actabp.pl/pdf/3_2014/531.pdf
Subject:
QR180 Immunology;
QR355 Virology
Identifier: http://eprints.ibb.waw.pl/806/1/531.pdf ;
Chroboczek, Jadwiga and Szurgot, Inga and Szolajska, Ewa (2014) Virus-like particles as vaccine. Acta biochimica Polonica, 61 (3). pp. 531-9. ISSN 1734-154X
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Virus-like particles as vaccine.

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