Object's details: RT-PCR Analysis of TOPBP1 Gene Expression in Hereditary Breast Cancer

Provider:Repozytorium Uniwersytetu Łódzkiego

Description

Title:
RT-PCR Analysis of TOPBP1 Gene Expression in Hereditary Breast Cancer
Creator:
Forma, Ewa;
Bernaciak, Magdalena;
Romanowicz-Makowska, Hanna;
Bryś, Magdalena
Contributor:
Forma Ewa - Department of Cytobiochemistry, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland;
Bernaciak Magdalena - Department of Cytobiochemistry, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland;
Romanowicz-Makowska Hanna - Department of Clinical Pathomorphology, Polish Mother's Memorial Hospital, Research Institute, Rzgowska 281/289, 93-338 Łódź, Poland;
Bryś Magdalena - Department of Cytobiochemistry, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland
Description:
Hereditary predisposition to breast cancer determined in large part by loss of function mutations in one of two genes BRCA1 and BRCA2. Besides BRCA1 and BRCA2 other genes are also likely to be involved in hereditary predisposition to breast cancer. TopBP1 protein is involved in DNA replication, DNA damage checkpoint response and transcriptional regulation. Expression of TopBP1 gene at the mRNA level was analyzed by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) in 94 samples of hereditary breast cancer. Analysis of TopBP1 mRNA level showed that expression of TopBP1 is significantly downregulated in poorly differentiated breast cancer (grade III according Bloom-Richardson system (P<0.05).
Object availability:
free access
Rights:
This content is open access.
Date:
2015.06.17;
2011.03.04
Format:
application/pdf
Publisher:
Wydawnictwo Uniwersytetu Łódzkiego
Relation:
Folia Biologica et Oecologica;6
Subject:
TopBP1;
gene expression;
RT-PCR;
hereditary breast cancer
Identifier:
1730-2366;
http://hdl.handle.net/11089/9868 ;
10.2478/v10107-009-0006-1
Data provider:
Repozytorium Uniwersytetu Łódzkiego

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