Description

• Title:
  The Complex Bidirectional Relationship Between Depression and Cardiovascular Disease
• Creator:
  Robak, Jakub;
  Telega, Stanisław;
  Bollin, Paweł;
  Szymczak, Urszula;
  Lachór, Wojciech Wiesław;
  Solarz, Monika Barbara;
  Piekarska, Julia;
  Solarz, Justyna Maria;
  Wawrzyńców, Jakub Tomasz;
  Cyrkler, Weronika
• Description:
  This systematic review establishes a robust bidirectional relationship between depression and cardiovascular disease (CVD) mediated by interconnected biological pathways including autonomic dysfunction, chronic inflammation, and endothelial impairment. Depression significantly increases CVD risk while CVD elevates depression susceptibility, creating a self-perpetuating cycle with worse clinical outcomes. Women with CVD demonstrate particular vulnerability to depression, necessitating gender-sensitive approaches. Current evidence supports integrated management strategies incorporating routine depression screening, selective serotonin reuptake inhibitors (SSRIs) like sertraline, and cognitive-behavioral therapy within cardiac care. However, optimal treatment requires addressing both conditions simultaneously through collaborative care models.  Future research priorities include elucidating causal mechanisms, developing biomarkers for risk stratification, and testing interventions targeting shared pathways. These findings underscore the urgent need for healthcare systems to implement holistic approaches that bridge mental and cardiovascular health, ultimately improving outcomes for this high-risk population.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2025 Jakub Robak, Stanisław Telega, Paweł Bollin, Urszula Szymczak, Wojciech Wiesław Lachór, Monika Barbara Solarz, Julia Piekarska, Justyna Maria Solarz, Jakub Tomasz Wawrzyńców, Weronika Cyrkler;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2025.05.11
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 41 (2025); 60058;
  Quality in Sport; Vol. 41 (2025); 60058;
  2450-3118
• Format:
  application/pdf
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/60058/42504
• Subject:
  depression;
  cardiovascular disease;
  epidemiology;
  pathophysiology;
  autonomic dysfunction;
  inflammation;
  endothelial dysfunction;
  platelet activation;
  neuroendocrine dysregulation;
  gender differences;
  treatment strategies;
  integrated care
• Identifier: https://apcz.umk.pl/QS/article/view/60058
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text