Object's details: Cardiac arrhythmias in pulmonary hypertension: A review of mechanisms, prevalence, clinical significance, and patient functional capacity

Provider:Akademicka Platforma Czasopism

Description

Title:
Cardiac arrhythmias in pulmonary hypertension: A review of mechanisms, prevalence, clinical significance, and patient functional capacity
Creator:
Rafałowicz, Adam;
Wojciechowska, Urszula, Justyna;
Mierzejewski, Jakub;
Łuniewski, Bartosz;
Macko, Angelika;
Olszańska, Monika;
Lauko, Kamil, Klaudiusz;
Sokół, Aleksandra;
Mościszko, Klaudia;
Hakało, Dominika
Description:
Introduction:Pulmonary hypertension is a chronic cardiovascular disease defined by a mean pulmonary artery pressure (mPAP) of > 20 mmHg, as measured by right heart catheterization (RHC). Rhythm disturbances are relatively common in this condition and significantly worsen patient prognosis. Elucidating the mechanisms that drive arrhythmia development may help identify therapeutic intervention strategies to enhance patient outcomes. Materials and methods:We performed a literature review of epidemiology, pathogenesis, and clinical impact of cardiac arrhythmias in Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH), analysing registry data, histopathological and electrophysiological studies, and clinical outcomes. Results:Supraventricular arrhythmias (SVA) occur in 10–33 % of patients, rising to ~30 % over 10 years. Key mechanisms include atrial stretch and fibrosis, autonomic imbalance, and right ventricular ischemia. Arrhythmias correlate with reduced cardiac output, impaired exercise capacity, and increased mortality. Conclusions:Early detection and maintenance of sinus rhythm enhance survival and functional capacity, highlighting the necessity of research and interventions directed at atrial remodelling, neurohormonal modulation and myocardial ischaemia.
Object availability:
free access
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
Prawa autorskie (c) 2025 Adam Rafałowicz, Urszula, Justyna Wojciechowska, Jakub Mierzejewski, Bartosz Łuniewski, Angelika Macko, Monika Olszańska, Kamil, Klaudiusz Lauko, Aleksandra Sokół, Klaudia Mościszko, Dominika Hakało
Date:
2025.06.17
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Quality in Sport; Tom 42 (2025); 60892;
Quality in Sport; Vol. 42 (2025); 60892;
2450-3118
Format:
application/pdf
Publisher:
University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
Relation: https://apcz.umk.pl/QS/article/view/60892/42872
Subject:
pulmonary hypertension;
supraventricular arrhythmias;
PAH;
CTEPH;
heart remodelling
Identifier: https://apcz.umk.pl/QS/article/view/60892
Data provider:
Akademicka Platforma Czasopism

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