Description

• Title:
  Is immunosuppressive therapy an effective treatment for COVID-19? – literature review
• Creator:
  Ostrowska, Barbara;
  Kołodziejczyk, Kacper;
  Branewska, Justyna;
  Hop, Izabela;
  Matysek, Mikołaj;
  Olszanicka, Anna;
  Imioło, Jan;
  Maciąg, Anna;
  Niemiec, Rafał;
  Galas, Adam
• Description:
  Introduction: The disease caused by SARS-CoV-2 is associated with a dysregulated immune response and a generalized inflammatory response. Therefore, during the search for effective therapy, attention was paid to drugs affecting and stabilizing such a response - tocilizumab, sarilumab, siltuximab, anakinra, baricitinib.Purpose of the work: Evaluation of the impact of immunosuppressant therapy on the course of the disease caused by the SARS-CoV-2 virus.Material and methods: The work was based on a review of available medical publications about immunosuppressive therapy for COVID-19 treatment. The literature in the PubMed and Google Scholar databases was searched based on the following keywords: tocilizumab, sarilumab, siltuximab, baricitinib, COVID-19, SARS-CoV-2, immunosuppressive therapy.Conclusion: Based on the analysis of the literature, the most effective therapeutic option seems to be tocilizumab. Promising alternatives may be sarilumab and siltuximab as they have the same target point of action. However, it is necessary to conduct further tests on their operation. The use of baricitinib may be useful, but probably only in certain circumstances. Anakinra proved to be much less effective. It should therefore be used with great caution.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2023 Barbara Ostrowska, Kacper Kołodziejczyk, Justyna Branewska, Izabela Hop, Mikołaj Matysek, Anna Olszanicka, Jan Imioło, Anna Maciąg, Rafał Niemiec, Adam Galas;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2023.05.15
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 29 No. 1 (2023); 45-51;
  Journal of Education, Health and Sport; Tom 29 Nr 1 (2023); 45-51;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/43633/35564
• Subject:
  COVID-19;
  SARS-CoV-2;
  immunosuppressive therapy;
  tocilizumab;
  sarilumab;
  siltuximab;
  baricitinib
• Identifier: https://apcz.umk.pl/JEHS/article/view/43633
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text