Object's details: Why the lungs became a target organ due to ischemic-reperfusion syndrome of the limb, caused by the use of haemostatic tourniquet

Provider:Akademicka Platforma Czasopism

Description

Title:
Why the lungs became a target organ due to ischemic-reperfusion syndrome of the limb, caused by the use of haemostatic tourniquet
Creator:
Volotovska, Nataliya
Description:
Much attention has been paid to the ambiguous effects of the tourniquets and hemostatic bandages - namely the local and systemic consequences of planned operations, as well as the changes that occur after the cessation of bleeding from a wounded limb on the battlefield. However, there is still no consensus on the ischemic-reperfusion syndrome (IRS). Aim. Detect changes in the activity of lipid peroxidation in lung tissue on the background of experimental modifications of IRS. For this goal 260 male white rats aged 5-5.5 months were divided into 5 experimental groups: 1) EG1 - imposition of the tourniquet on the thigh for 2 h; 2) EG2 - modeling of venous blood loss in the amount of 40% of the volume of circulating blood; 3) EG3 - a combination of hemostatic tourniquet and blood loss 4) EG4 - mechanical injury to the thigh bone 5) a combination of hemostatic tourniquet and mechanical trauma. The biochemical study in 10 % lung homogenate was performed by reacting of peroxidation derivatives with thiobarbituric acid. Conclusions. It was found that each of these types of intervention caused the activation of lipid peroxidation in the lungs. The peculiarities of the reaction were such increase of this rate, which was the highest on the background of blood loss combined with the use of a tourniquet. However, the concentration of malonic dialdehyde was higher in the group where the imposition of the tourniquet was combined with mechanical trauma, compared with isolated mechanical trauma of the thigh. This has shown the role of the tourniquet as a factor that complicated the course of traumatic disease due to ischemic reperfusion.
Object availability:
free access
Rights:
Prawa autorskie (c) 2020 © The Author(s)
Date:
2020.06.25
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 10 No. 6 (2020); 186-198;
Journal of Education, Health and Sport; Tom 10 Nr 6 (2020); 186-198;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.06.021/25931
Subject:
ischemia-reperfusion syndrome;
lungs;
trauma;
blood loss;
hemostatic tourniquet;
lipid peroxidation
Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.06.021
Data provider:
Akademicka Platforma Czasopism

Similar objects

Why the lungs became a target organ due to ischemic-reperfusion syndrome of the limb, caused by the use of haemostatic tourniquet

Creator:Volotovska, Nataliya

Date:2020.06.25

Type:text

Therapeutic effect of thiocetam on the manifestations of ischemia-reperfusion complicated by massive blood loss and mechanical trauma

Creator:Volotovska, Nataliya

Date:2020.12.24

Type:text

Amount of generators of reactive oxygen species as a marker of organism damage on the background of experimental limb ischemia-reperfusion

Creator:Volotovska, Nataliya

Date:2021.01.29

Type:text

Morphological changes in lung tissue in case of blunt abdominal trauma, massive blood loss, and ischemia-reperfusion of the limb

Creator:Fedoseeva, O. V.

Date:2020.08.31

Type:text

Significance of lipid peroxidation processes in renal excretory dysfunction in cases of acute blood loss complicated by limb ischemia-reperfusion and its correction

Creator:Shatskyi, V. V. | Hudyma, A. A.

Date:2019.11.29

Type:text

The effect of cranioskeletal trauma complicated by blood loss on the functional state of the liver in the early period of traumatic disease in rats with different resistance to hypoxia and their correction

Creator:Sikirynska, D. O. | Hudyma, A. A. | Shulhai, A. H. | Pokhodun, K. A.

Date:2021.02.26

Type:text

Wound packing trainee construction

Date:2023.08.08

Type:text

Lipid peroxidation in liver and kidneys of rats intoxicated with vanadium

Creator:Zaporowska, Halina | Ścibor, Agnieszka

Date:1997

Type:other

Federacja Bibliotek Cyfrowych

Object's details: Why the lungs became a target organ due to ischemic-reperfusion syndrome of the limb, caused by the use of haemostatic tourniquet

Description

Similar objects