Description

• Title:
  The basic biology of erbB-2 and its participation in colorectal cancers
• Creator:
  Stawińska, Magdalena;
  Bryś, Magdalena;
  Krajewska, Wanda M.
• Contributor:
  University of Łódź, Department of Cytobiochemistry;
  zreg@biol.uni.lodz.pl
• Description:
  ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers are formed and cell signalling is stronger, resulting in enhanced responsiveness to growth factors and malignant growth. This explains why ErbB-2 overexpression is an indicator of poor prognosis in colorectal cancers and may be predictive of response to treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.;
  Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej naukę.
• Object availability:
  free access
• Date:
  2015.10.05;
  2005
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Wydawnictwo Uniwersytetu Łódzkiego
• Relation:
  Acta Universitatis Lodziensis. Folia Biologica et Oecologica;2
• Subject:
  ErbB-2;
  colorectal cancers;
  signal transduction;
  tumour growth
• Identifier:
  1730-2366;
  http://hdl.handle.net/11089/12099
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  seek permission
• Type:
  image