Object's details: PARP Inhibitors in the Treatment of Ovarian Cancer: a review of the latest research

Provider:Akademicka Platforma Czasopism

Description

Title:
PARP Inhibitors in the Treatment of Ovarian Cancer: a review of the latest research
Creator:
Zuzak, Andrzej Paweł;
Satora, Małgorzata;
Cieślik-Porębska, Magdalena;
Kułak, Krzysztof;
Niewiadomska , Jagoda
Description:
Introduction Ovarian cancer is a leading cause of cancer mortality globally due to late-stage diagnosis and limited treatment options. PARP inhibitors have shown promise as effective treatments for recurrent and various stages of ovarian cancer. Aim of the Study This study reviews the efficacy and application of PARP inhibitors in ovarian cancer treatment over the past 15 years, focusing on literature from the PubMed database post-2009 and considering FDA and EMA guidelines. Review methods A literature review was conducted using the PubMed database, focusing on studies published after 2009. The review also incorporated recommendations from the FDA and the European Medicines Agency regarding the use of PARP inhibitors in ovarian cancer treatment. Results The findings highlight the substantial impact of PARP inhibitors on ovarian cancer treatment, improving PFS and overall outcomes. Olaparib, niraparib, and rucaparib have become integral to ovarian cancer management, offering effective options for patients with BRCA mutations or homologous recombination deficiencies. These inhibitors have been validated in multiple clinical trials, underscoring their robustness and effectiveness. Combination therapies, such as olaparib with bevacizumab, further enhance therapeutic outcomes, showcasing the potential for synergistic effects. Summary PARP inhibitors represent a significant advancement in ovarian cancer treatment, offering improved survival outcomes for patients with specific genetic profiles. Their integration into standard care protocols underscores their importance and efficacy, providing valuable therapeutic options in the fight against ovarian cancer.
Object availability:
free access
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
Prawa autorskie (c) 2025 Andrzej Paweł Zuzak, Małgorzata Satora, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska
Date:
2025.02.21
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 78 (2025); 57677;
Journal of Education, Health and Sport; Tom 78 (2025); 57677;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/57677/41465
Subject:
PARP inhibitors;
ovarian cancer;
ovarian cancer treatment
Identifier: https://apcz.umk.pl/JEHS/article/view/57677
Data provider:
Akademicka Platforma Czasopism

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