Description

• Title:
  The solution to drug resistance of Gram-negative bacteria – Cefiderocol
• Creator:
  Kołodziej, Magdalena;
  Gorczyca, Kamila;
  Jastrzębska, Ilona;
  Węgorowski, Paweł;
  Wieczorek, Michał
• Description:
  Introduction: A major public health problem is the emergence of anti-gram-negative antimicrobial resistance worldwide. Cefiderocol is a new agent targeting Gram-negative bacteria, including strains with resistance to carbapenems. Aim of the study: Analysis of the efficiency of cefiderocol in the treatment of infections caused by gram-negative bacteria, the drug's mechanism of action and pharmacokinetics and pharmacodynamics of the drug. Material and Methods: Search of the PubMed database using the following keywords: cefiderocol, resistance, gram negative bacteria. Only full-length articles were taken into consideration. Results: The studies show that cefiderocol is active against Enterobacteriaceae, P. aeruginosa, B. cepacia and A. baumannii and effective in the treatment of pneumonia in both non-ventilated and ventilated patients. Moreover, it has been used in the treatment of sepsis as a rescue therapy. Conclusion: Cefiderocol is an effective treatment for infections caused by gram-negative bacteria. However, more research is needed to learn more about the use of this drug, side effects and resistance mechanisms.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2023 Magdalena Kołodziej, Kamila Gorczyca, Ilona Jastrzębska, Paweł Węgorowski, Michał Wieczorek;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2023.05.23
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 33 No. 1 (2023); 17-21;
  Journal of Education, Health and Sport; Tom 33 Nr 1 (2023); 17-21;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/43777/35643
• Subject:
  cefiderocol;
  resistance;
  gram negative bacteria
• Identifier: https://apcz.umk.pl/JEHS/article/view/43777
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text